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Neurofilament light (NfL) as biomarker in serum and CSF in status epilepticus by Nils G. Margraf; Justina Dargvainiene; Emily Theel; Frank Leypoldt; Wolfgang Lieb; Andre Franke; Klaus Berger; Jens Kuhle; Gregor Kuhlenbaeumer is a Medicine article available to read on EtoBox.

What is Neurofilament light (NfL) as biomarker in serum and CSF in status epilepticus about?

## Objective We explored the potential of neurofilament light chain (NfL) in serum and cerebrospinal fluid as a biomarker for neurodestruction in status epilepticus. ## Methods In a retrospective analysis, we measured NfL in serum and cerebrospinal fluid samples of patients with status epilepticus using a highly sensitive single-molecule array technique (Simoa). Status epilepticus was diagnosed according to ILAE criteria. Additionally, we employed an alternative classification with more emphasis on the course of status epilepticus. We used data from three large control groups to compare NfL in status epilepticus versus neurologically healthy controls. ## Results We included 28 patients (mean age: 69.4 years, SD: 15 years) with a median status duration of 44 h (IQR: 80 h). Twenty-one patients (75%) suffered from convulsive status epilepticus and seven (25%) from non-convulsive status epilepticus. Six patients died (21%). Cerebrospinal fluid and serum NfL concentrations showed a high correlation (__r__ = 0.73, __p__ < 0.001, Pearson). The main determinant of NfL concentration was the status duration. NfL concentrations did not differ between convulsive status epilepticus and convulsi

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Author

Nils G. Margraf; Justina Dargvainiene; Emily Theel; Frank Leypoldt; Wolfgang Lieb; Andre Franke; Klaus Berger; Jens Kuhle; Gregor Kuhlenbaeumer

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)