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Seroprevalence of Kaposi's sarcoma-associated herpesvirus and risk factors in Xinjiang, China by Bishi Fu; Feng Sun; Baolin Li; Lei Yang; Yan Zeng; Xiulian Sun; Fanhong Xu; Simon Rayner; Moraima Guadalupe; Shou-Jiang Gao; Linding Wang is a Medicine article available to read on EtoBox.

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## Abstract Xinjiang, China is an endemic area for Kaposi's sarcoma (KS) but the seroprevalence of Kaposi's sarcoma‐associated herpesvirus (KSHV) and risk factors remain undefined. In this study, antibodies to one KSHV latent protein (ORF73) and two KSHV lytic proteins (ORF65 and ORF‐K8.1) were examined in 2,228 subjects from the general population and 37 subjects infected with HIV‐1 in Xinjiang, and 560 subjects from the general population in Hubei, a low KS incidence region. The serostatus of a serum sample was defined based on positive results in any one of the three serologic assays. The seroprevalence of KSHV in the general population was higher in Xinjiang than in Hubei (19.2% vs. 9.5%; odds ratios [OR], 2.28; 95% confidence interval [CI], 1.68–3.08; __P__ < 0.001). Among the ethnic groups in Xinjiang, 68 (15.8%) Han, 182 (20.7%) Uygur, 140 (19.9%) Hazakh, 9 (33.3%) Xibo, and 29 (16.8%) Hui were KSHV‐seropositive, respectively. Compared to the Han, the latter groups had an increase in the risk of KSHV of 62.2%, 63.8%, 180.1%, and 30.2% (__P__ = 0.003, 0.004, 0.018, and 0.286, respectively). Subjects aged 50 had a seroprevalence of KSHV of 11.8%, 17.9%, and 24.6%, respectivel

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Author

Bishi Fu; Feng Sun; Baolin Li; Lei Yang; Yan Zeng; Xiulian Sun; Fanhong Xu; Simon Rayner; Moraima Guadalupe; Shou-Jiang Gao; Linding Wang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)

Published

2009

Language

EN

Field

Medicine (Health Sciences)