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Evolutionary Relationships of the Carbamoylphosphate Synthetase Genes by Maurice J. B. van den Hoff; Ard Jonker; Jaap J. Beintema; Wouter H. Lamers is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Evolutionary Relationships of the Carbamoylphosphate Synthetase Genes about?

Carbamoylphosphate is a common intermediate in the metabolic pathways leading to the biosynthesis of arginine and pyrimidines. The amino acid sequences of all available proteins that catalyze the formation of carbamoylphosphate were retrieved from Genbank and aligned to estimate their mutual phylogenetic relations. In gram-negative bacteria carbamoylphosphate is synthesized by a two-subunit enzyme with glutaminase and carbamoylphosphate synthetase (CPS) activity, respectively. In gram-positive bacteria and lower eukaryotes this two-subunit CPS has become dedicated to arginine biosynthesis, while in higher eukaryotes the two subunits fused and subsequently lost the glutaminase activity. The CPS dedicated to pyrimidine synthesis is part of a multifunctional enzyme (CPS II), encoding in addition dihydroorotase and aspartate transcarbamoylase. Evidence is presented to strengthen the hypothesis that the two "kinase" subdomains of all CPS isozymes arose from a duplication of an ancestral gene in the progenote. A further duplication of the entire CPS gene occurred after the divergence of the plants and before the divergence of the fungi from the eukaryotic root, generating the two isoenzy

Who reads Evolutionary Relationships of the Carbamoylphosphate Synthetase Genes?

Author

Maurice J. B. van den Hoff; Ard Jonker; Jaap J. Beintema; Wouter H. Lamers

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0022-2844)

Published

1995

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)