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Transcriptional responses of Daphnis nerii larval midgut to oral infection by Daphnis nerii cypovirus-23 by Wendong Kuang; Chenghua Yan; Zhigao Zhan; Limei Guan; Jinchang Wang; Junhui Chen; Jianghuai Li; Guangqiang Ma; Xi Zhou; Liang Jin is a Medicine article available to read on EtoBox.
What is Transcriptional responses of Daphnis nerii larval midgut to oral infection by Daphnis nerii cypovirus-23 about?
## Background: Daphnis nerii cypovirus-23 (dncpv-23) is a new type of cypovirus and has a lethal effect on the oleander hawk moth, daphnis nerii which feeds on leave of oleander and catharanthus et al. after dncpv-23 infection, the change of daphnis nerii responses has not been reported. ## Methods: To better understand the pathogenic mechanism of dncpv-23 infection, 3rd-instar daphnis nerii larvae were orally infected with dncpv-23 occlusion bodies and the transcriptional responses of the daphnis nerii midgut were analyzed 72 h post-infection using rna-seq. ## Results: The results showed that 1979 differentially expressed daphnis nerii transcripts in the infected midgut had been identified. kegg analysis showed that protein digestion and absorption, toll and imd signaling pathway were down-regulated. based on the result, we speculated that food digestion and absorption in insect midgut might be impaired after virus infection. in addition, the down-regulation of the immune response may make d. nerii more susceptible to bacterial infections. glycerophospholipid metabolism and xenobiotics metabolism were up-regulated. these two types of pathways may affect the viral replication and x
Who reads Transcriptional responses of Daphnis nerii larval midgut to oral infection by Daphnis nerii cypovirus-23?
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- Author
- Wendong Kuang; Chenghua Yan; Zhigao Zhan; Limei Guan; Jinchang Wang; Junhui Chen; Jianghuai Li; Guangqiang Ma; Xi Zhou; Liang Jin
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)