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Can I read hUC-MSCs therapy for Crohn’s disease: efficacy in TNBS-induced colitis in rats and pilot clinical study on EtoBox?
hUC-MSCs therapy for Crohn’s disease: efficacy in TNBS-induced colitis in rats and pilot clinical study by Qinjuan Sun; Shan Li; Ritian Lin; Guangxi Zhao; Jinlai Lu; Bin Liu; Miao Hu; Wei Wang; Xiaoqing Yang; Yushuang Wei; Wenwen Jia; Yanni Hu; Wei Zhang; Jiawen Zhu; Daxiang Cui; Lan Zhong is a Medicine article available to read on EtoBox.
What is hUC-MSCs therapy for Crohn’s disease: efficacy in TNBS-induced colitis in rats and pilot clinical study about?
## Summary ## Background The use of mesenchymal stem cells (MSCs) has recently emerged as a promising new therapeutic strategy for many diseases including perianal fistulizing Crohn’s disease (CD). Whether hUC-MSCs can promote the healing of luminal ulcer in CD has not been studied so far. ## Methods The model of TNBS-induced colitis in rats was used to confirm the efficacy of hUC-MSCs in the treatment of CD. Then, seventeen CD patients refractory to or unsuitable for currently available therapies were enrolled and received once submucosal local injection through colonoscopy combined with once intravenous drip on the next day. All patients received a 24-week follow-up. Clinical and laboratory assessments were monitored at baseline, week 4, 8, 12, and 24. Endoscopic evaluations were conducted at baseline and week 12. Mucosal specimens were obtained at the margin of lesions by endoscopy biopsies and used for RNA sequencing. Two hUC-MSCs co-culture systems were established in vitro, one with the mucosa specimens and the other with M1 macrophages induced from THP1. The expressions of genes representing inflammation (TNFα, IL-6, and IL-1β) and intestinal barrier function (ZO1, CLAUDIN1,
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- Author
- Qinjuan Sun; Shan Li; Ritian Lin; Guangxi Zhao; Jinlai Lu; Bin Liu; Miao Hu; Wei Wang; Xiaoqing Yang; Yushuang Wei; Wenwen Jia; Yanni Hu; Wei Zhang; Jiawen Zhu; Daxiang Cui; Lan Zhong
- Publisher
- Elsevier
- Published
- 2024
- Language
- EN
- Field
- Medicine (Life Sciences)