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Can I read Transforming Growth Factor-β2 Is Elevated in Skeletal Muscle Disorders on EtoBox?
Transforming Growth Factor-β2 Is Elevated in Skeletal Muscle Disorders by Nobuyuki Murakami; Ian S. McLennan; Ikuya Nonaka; Kyoko Koishi; Christina Baker; Graeme Hammond-Tooke is a Medicine article available to read on EtoBox.
What is Transforming Growth Factor-β2 Is Elevated in Skeletal Muscle Disorders about?
The transforming growth factor betas (TGF-s) are multifunctional growth factors that act on both fibroblasts and myosatellite cells. In rodent models of muscle diseases, high levels of TGF-2 are expressed by myogenic cells. We have examined whether the expression of TGF-2 is also elevated in diseased human muscles. The disorders examined were Duchenne muscular dystrophy, myotonic dystrophy, myotubular myopathy, spinal muscular atrophy, and amyotrophic lateral sclerosis. The levels of TGF-2 immunoreactivity were elevated in atrophic, necrotic, and regenerating fibers and in fibers with central nuclei or cytoplasmic masses, irrespective of whether fibrosis was present. We therefore suggest that TGF-2 is important for muscle repair and that the presence of a TGF- within a muscle only leads to fibrosis if certain other factors are present.
Who reads Transforming Growth Factor-β2 Is Elevated in Skeletal Muscle Disorders?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Nobuyuki Murakami; Ian S. McLennan; Ikuya Nonaka; Kyoko Koishi; Christina Baker; Graeme Hammond-Tooke
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0148-639X)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)