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Can I read Penicillin-binding protein 1b encoded by mrcB gene mediates the enhancement of biofilm formation by sub-inhibitory concentrations of cefotaxime in monophasic Salmonella Typhimurium strain SH16SP46 on EtoBox?
Penicillin-binding protein 1b encoded by mrcB gene mediates the enhancement of biofilm formation by sub-inhibitory concentrations of cefotaxime in monophasic Salmonella Typhimurium strain SH16SP46 by Mengran Wang; Jing Wang; Tian Li; Xue Bao; Pengyun Li; Xiuling Zhang; Qi Huang; Xianrong Meng; Shaowen Li is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Penicillin-binding protein 1b encoded by mrcB gene mediates the enhancement of biofilm formation by sub-inhibitory concentrations of cefotaxime in monophasic Salmonella Typhimurium strain SH16SP46 about?
Abstract Development of cefotaxime-resistance and biofilm formation increase the difficulty to prevent and control the infection and contamination of Salmonella, one of the most important foodborne and zoonotic bacterial pathogen. Our previous study observed that 1/8 MIC of cefotaxime induced the enhancement of biofilm formation and filamentous morphological change by a monophasic Salmonella Typhimurium strain SH16SP46. This study was designed to explore the role of three penicillin-binding proteins (PBPs) in mediating the induction effect of cefotaxime. Three deletion mutants of the genes mrcA, mrcB, and ftsI, encoding the proteins PBP1a, PBP1b, and PBP3, respectively, were constructed using the parental Salmonella strain SH16SP46. Gram staining and scanning electron microscopy showed that these mutants showed normal morphology comparable to the parental strain without cefotaxime treatment. However, under the stress of 1/8 MIC of cefotaxime, the strains WT, ΔmrcA, and ΔftsI, rather than ΔmrcB, exhibited filamentous morphological change. Moreover, cefotaxime treatment significantly enhanced biofilm formation by the strains WT, ΔmrcA, and ΔftsI, but not by the ΔmrcB strain. The comp
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- Author
- Mengran Wang; Jing Wang; Tian Li; Xue Bao; Pengyun Li; Xiuling Zhang; Qi Huang; Xianrong Meng; Shaowen Li
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)