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ModuleMaster: A new tool to decipher transcriptional regulatory networks by Clemens Wrzodek; Adrian Schröder; Andreas Dräger; Dierk Wanke; Kenneth W. Berendzen; Marcel Kronfeld; Klaus Harter; Andreas Zell is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is ModuleMaster: A new tool to decipher transcriptional regulatory networks about?

In this article we present ModuleMaster, a novel application for finding cis-regulatory modules (CRMs) in sets of co-expressed genes. The application comes with a newly developed method which not only considers transcription factor binding information but also multivariate functional relationships between regulators and target genes to improve the detection of CRMs. Given only the results of a microarray and a subsequent clustering experiment, the program includes all necessary data and algorithms to perform every step to find CRMs. This workbench possesses an easy-to-use graphical user interface, together with job-processing and command-line options, making ModuleMaster a sophisticated program for large-scale batch processing. The detected CRMs can be visualized and evaluated in various ways, i.e., generating GraphML- and R-based whole regulatory network visualizations or generating SBML files for subsequent analytical processing and dynamic modeling. ## Availability: Modulemaster is freely available to academics as a webstart application and for download at http://www.ra.cs.uni-tuebingen.de/software/modulemaster/, including comprehensive documentation.

Who reads ModuleMaster: A new tool to decipher transcriptional regulatory networks?

Author

Clemens Wrzodek; Adrian Schröder; Andreas Dräger; Dierk Wanke; Kenneth W. Berendzen; Marcel Kronfeld; Klaus Harter; Andreas Zell

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0303-2647)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)