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Can I read A Supramolecular Self-assembled Nanomaterial for Synergistic Therapy of Immunosuppressive Tumor on EtoBox?
A Supramolecular Self-assembled Nanomaterial for Synergistic Therapy of Immunosuppressive Tumor by Tianjiao Wang; Zhiyuan Gao; Yufan Zhang; Yuning Hong; Youhong Tang; Ke Shan; Xianglong Kong; Zhiming Wang; Yang Shi; Dan Ding is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is A Supramolecular Self-assembled Nanomaterial for Synergistic Therapy of Immunosuppressive Tumor about?
Triple negative breast cancer (TNBC) is an immunosuppressive "cold" tumor that lacks immune cell infiltration and activation, resulting in a poor response to immune checkpoint blockade (ICB) therapies. In addition, TNBC is poorly responsive to targeted therapies due to the absence of efficient molecular targets. A strategy that can block molecular signal transduction, stimulate immunogenicity, and activate the immune response is a promising approach to achieve ideal clinical benefit. Herein, we designed and synthesized an aggregation-induced emission luminogen (AIEgen)-conjugated self-assembling peptide that targets epidermal growth factor receptor (EGFR), named TPA-FFG-LA. TPA-FFG-LA peptides form nanoassemblies on the surface of EGFR-positive TNBC cells and are internalized into cells through endocytosis, which inhibit EGFR signaling transduction and provoke lysosomal membrane permeabilization (LMP). Upon light irradiation, the aggregated AIEgens produce massive reactive oxygen species (ROS) to exacerbate LMP and trigger immunogenic cell death (ICD), resulting in elimination of residual EGFR-negative tumor cells and exerting long-term antitumor effects. The in vitro and in vivo e
Who reads A Supramolecular Self-assembled Nanomaterial for Synergistic Therapy of Immunosuppressive Tumor?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Tianjiao Wang; Zhiyuan Gao; Yufan Zhang; Yuning Hong; Youhong Tang; Ke Shan; Xianglong Kong; Zhiming Wang; Yang Shi; Dan Ding
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)