Can I read Angiogenesis and Metabolism: Entwined for Therapy Resistance on EtoBox?

Angiogenesis and Metabolism: Entwined for Therapy Resistance by Gabriela Jiménez-Valerio; Oriol Casanovas is a Medicine article available to read on EtoBox.

What is Angiogenesis and Metabolism: Entwined for Therapy Resistance about?

Angiogenesis and metabolism are entwined processes that permit tumor growth and progression. Blood vessel supply is necessary for tumor survival not only by providing oxygen and nutrients for anabolism but also by removing waste products from cellular metabolism. On the other hand, blocking angiogenesis with antiangiogenic therapies shows clinical benefits in treating several tumor types. Nevertheless, resistance to therapy emerges over time. In this review we discuss a novel mechanism of adaptive resistance involving metabolic adaptation of tumor cells, and we also provide examples of tumor adaptation to therapy, which may represent a new mechanism of resistance in several types of cancer. Thus, targeting this metabolic tumor adaptation could be a way to avoid resistance in cancer patients.

Who reads Angiogenesis and Metabolism: Entwined for Therapy Resistance?

Author

Gabriela Jiménez-Valerio; Oriol Casanovas

Publisher

Elsevier BV

Published

2017

Language

EN

Field

Medicine (Life Sciences)