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Classification of PR-positive and PR-negative subtypes in ER-positive and HER2-negative breast cancers based on pathway scores by Hu, Taobo (author);Chen, Yan (author);Liu, Yiqiang (author);Zhang, Danhua (author);Pan, Jiankang (author);Long, Mengping (author) is a Mathematics article available to read on EtoBox.

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## Purpose PR loss in ER+/HER2- breast cancer indicates worse prognosis and insensitivity to anti-estrogen therapy, while the mechanisms of PR loss in ER+/HER2- breast cancer remain unrevealed. ## Methods In this study, ER+/PR+/HER2- and ER+/PR-/HER2- breast cancer cases from TCGA were used. 1387 pathways were analyzed and used as variables for classifying the two groups with LASSO regression. ## Results ER+/PR+/HER2- and ER+/PR-/HER2- breast cancer groups can be classified by a combination of 13 pathways using their activity score. Among the 13 pathways, those involving growth factors and ion-channel transporters were most significant in the distinction, followed by pathways involving immune modulation and cell metabolism. Two growth factor pathways, EGF and IGF-1, were deferentially regulated in ER+/PR+/HER2- and ER+/PR-/HER2- groups. ## Conclusions In conclusion, this study indicated in ER+/HER2- breast cancers the various status of PR expression can be an indication of molecular variation, particularly for the growth factor pathway activation. ## Supplementary Information The online version contains supplementary material available at 10.1186/s12874-021-01297-8.

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Author

Hu, Taobo (author);Chen, Yan (author);Liu, Yiqiang (author);Zhang, Danhua (author);Pan, Jiankang (author);Long, Mengping (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Mathematics (Physical Sciences)