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Induced CD and interaction of some porphyrin derivatives with α-helical polypeptides in aqueous solutions by Shoichi Ikeda; Takashi Nezu; Gotthold Ebert is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Absorption spectra and induced CD have been measured on aqueous solutions of watersoluble porphyrins with a-helical poly (L-glutamic acid) or a-helical poly (L-lysine) a t different mixing ratios. For the former, porphyrin is porphine-meso-tetra (4-N-methylpyridinium) (TMpyP) , and for the latter, it is porphine-meso-tetra( 4-benzenesulfonate) (TPPS) or porphine-meso-tetra( 4-benzoate) ( T P P C ) . All the solutions of porphyrinpolypeptide systems show hypochromism in the Soret band and induced CD in the Soret region. The CD is characterized by a positive band at a shorter wavelength and a stronger negative band at a longer wavelength. The hypochromicity and the magnitude of molar ellipticities are much larger for the TPPSand TPPC-poly (L-lysine) systems than for the TMpyP-poly (L-glutamic acid) system. Porphyrin ions bind to the a-helix electrostatically, and the two components of the Soret transition of porphyrin are subject to dissymmetric perturbation. TMpyP ions bind to the a-helix at isolated sites, while TPPS ions and TPPC ions are in pairs on the a-helix, that is, two ions bind consecutively and dissymmetrically. In the TMpyP-poly (L-glutamic acid) system a single CD band

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Author

Shoichi Ikeda; Takashi Nezu; Gotthold Ebert

Publisher

Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0006-3525)

Published

1991

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)