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1. Sickle cell disease is caused by genetic mutations that lead to abnormal hemoglobin production and red blood cell deformation. 2. Predisposing factors include mutated hemoglobin genes and low hemoglobin levels. 3. Contributing factors include certain ancestries, especially Southeast Asian. 4. Complications arise from hemolysis, ineffective erythropoiesis, and hypercoagulability, leading to anemia, organ damage, and other issues.

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STORAGE FILE

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