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Fish oil inhibits Δ6 desaturase activity in vivo: Utility in a dietary paradigm to obtain mice depleted of arachidonic acid by Amiram Raz; Nurit Kamin-Belsky; Fiorenza Przedecki; Mark G. Obukowicz is a Medicine article available to read on EtoBox.

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in mice that were alternately fasted and then refed an essentialfatty acid-dejicient (EFAD) diet, there u'as a rapid and substantial decline in tissue n-3 and n-6 polyunsaturatedfatty acids (PUFAs) and a corresponding increase in n-9,fatty acids. Combined in vivo actillities of A6 f A5 desaturases were quantified directly by measuring the conversion of "C-1inoleic acid (intraperitoneal injection) to '"C-arachidonic acid in liver lipids. A5 desaturase activi@ was quantified by measuring the conversion of "C-dihomo-y-linolenic acid (intraperitoneal injection) to 'JC-arachidonic acid in liver lipids. The combined A6 + A5 desaturase activities in EFAD mice was very similar to that in chow-fed control mice (3.5% vs. 33% conversion of '"C-linoleic acid to "C-arachidonic acid, respectively). Subsequent refeeding of EFAD mice with an EFAD diet supplemented with corn oil restored tissue n-6 PUFA levels, but did not alter A6 + A5 desaturase activities (33%). In contrast, subsequent refeeding of EFAD mice with a fish oil-supplemented diet markedly inhibited A6 + A5 desaturase activities (7%). Fatty acid analysis of the 1iver.s from the fish oil-fed mice showed that there was a depletion of th

Who reads Fish oil inhibits Δ6 desaturase activity in vivo: Utility in a dietary paradigm to obtain mice depleted of arachidonic acid?

Author

Amiram Raz; Nurit Kamin-Belsky; Fiorenza Przedecki; Mark G. Obukowicz

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0955-2863)

Published

1997

Language

EN

Field

Medicine (Health Sciences)