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Can I read Predictive assays of radiation response in patients with head and neck squamous cell carcinoma: A review of the institute gustave roussy experience on EtoBox?
Predictive assays of radiation response in patients with head and neck squamous cell carcinoma: A review of the institute gustave roussy experience by François Eschwege; Jean Bourhis; Theodore Girinski; Eric Lartigau; Marcelle Guichard; David Deblé; Lucina Kepta; G.D Wilson; B Luboinski is a Medicine article available to read on EtoBox.
What is Predictive assays of radiation response in patients with head and neck squamous cell carcinoma: A review of the institute gustave roussy experience about?
The aim of the study was to present the updated Institut Gustave Roussy experience of the predictive value of three biological parameters in patients with squamous cell carcinoma of the Head and Neck (HNSCC) treated with radiation therapy. Methods and Materials: Three parameters have been investigated independently: tumor cell kinetics (TS, Tpot and LI), oxygen tension measurements (P0 2 ) and intrinsic radiosensitivity (SF 2 Gy). Results: No relationship has been found between local-regional control and Tpot or LI in a series of 74 patients. Our data also support that the surviving fraction at 2 Gy, (SF 2 ) was unlikely to predict the clinical outcome in a series of 92 patients. Differences in P0 2 measurements have been observed between tumors, and tumor oxygenation was lower than that of normal tissue for the majority of patient. However P0 2 measurements did not predict clinical outcome, but further investigations are needed to draw definitive conclusions, given the limited number of patients entered in our study (35 patients). In addition, we were able to measure the three parameters in 10 patients showing no correlation between P0 2 , SF 2 and T pot . Conclusions: The method
Who reads Predictive assays of radiation response in patients with head and neck squamous cell carcinoma: A review of the institute gustave roussy experience?
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- Author
- François Eschwege; Jean Bourhis; Theodore Girinski; Eric Lartigau; Marcelle Guichard; David Deblé; Lucina Kepta; G.D Wilson; B Luboinski
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Health Sciences)