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Is the Hodgkin cell A T- or B-lymphocyte? recent evidence from geno- and immunophenotypic analysis andin-vitro cell lines by Dr. Hans G. Drexler; David B. Jones; Volker Diehl; Jun Minowada is a Medicine article available to read on EtoBox.

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The cellular derivation of Hodgkin (H) and Reed-Sternberg (RS) cells remains a controversial issue. A large body of conflicting results in the literature led to a variety of discordant speculations. The application of immunophenotyping, molecular biology and tissue culture provided additional means for investigations on the nature of H-RS cells. Using immunoenzymatic staining with monoclonal antibodies (McAbs) at the single cell level, H-RS cells from many, albeit not all cases, were shown to be positive for T-and/or B-cell markers; none of the cases were labelled by anti-myeloid or anti-monocyte/macrophage McAbs. A common feature of the otherwise heterogeneous immunoprofile is the expression of activation and proliferation antigens besides HLA-DR class I1 antigen and the X-hapten. Clonal rearrangements of T-cell receptor or immunoglobulin chain genes were found in 22 per cent of cases. The low frequency of positive samples might be due to the commonly low number of H-RS cells in the total population which can lay below the threshold of sensitivity for genotypic analysis. Several cell lines containing H-RS-like cells have been established. These cell lines have geno-and immunopheno

Who reads Is the Hodgkin cell A T- or B-lymphocyte? recent evidence from geno- and immunophenotypic analysis andin-vitro cell lines?

Author

Dr. Hans G. Drexler; David B. Jones; Volker Diehl; Jun Minowada

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0278-0232)

Published

1989

Language

EN

Field

Medicine (Health Sciences)