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This commentary discusses the study on the role of iodothyronine deiodinase 2 (DIO2) in cerebrovascular malformations, highlighting its elevation as an adaptive response in malformed vessels. The study found that increased DIO2 expression and thyroid hormone (TH) signaling can reduce brain hemorrhage and vascular anomalies in mouse models. The authors suggest that targeting TH signaling could provide a novel therapeutic approach for cerebrovascular disorders.

Author

Brain \u0026 Heart

Language

EN