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Pulmonary Rehabilitation Improves Survival in Patients with Idiopathic Pulmonary Fibrosis Undergoing Lung Transplantation by Juliessa Florian; Guilherme Watte; Paulo José Zimermann Teixeira; Stephan Altmayer; Sadi Marcelo Schio; Letícia Beatriz Sanchez; Douglas Zaione Nascimento; Spencer Marcantonio Camargo; Fabiola Adélia Perin; José de Jesus Camargo; José Carlos Felicetti; José da Silva Moreira is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract This study was conducted to evaluate whether a pulmonary rehabilitation program (PRP) is independently associated with survival in patients with idiopathic pulmonary fibrosis (IPF) undergoing lung transplant (LTx). This quasi-experimental study included 89 patients who underwent LTx due to IPF. Thirty-two completed all 36 sessions in a PRP while on the waiting list for LTx (PRP group), and 53 completed fewer than 36 sessions (controls). Survival after LTx was the main outcome; invasive mechanical ventilation (IMV), length of stay (LOS) in intensive care unit (ICU) and in hospital were secondary outcomes. Kaplan-Meier curves and Cox regression models were used in survival analyses. Cox regression models showed that the PRP group had a reduced 54.0% (hazard ratio = 0.464, 95% confidence interval 0.222–0.970, p = 0.041) risk of death. A lower number of patients in the PRP group required IMV for more than 24 hours after LTx (9.0% vs. 41.6% p = 0.001). This group also spent a mean of 5 days less in the ICU (p = 0.004) and 5 days less in hospital (p = 0.046). In conclusion, PRP PRP completion halved the risk of cumulative mortality in patients with IPF undergoing unilateral L

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Author

Juliessa Florian; Guilherme Watte; Paulo José Zimermann Teixeira; Stephan Altmayer; Sadi Marcelo Schio; Letícia Beatriz Sanchez; Douglas Zaione Nascimento; Spencer Marcantonio Camargo; Fabiola Adélia Perin; José de Jesus Camargo; José Carlos Felicetti; José da Silva Moreira

Publisher

Springer Science and Business Media LLC

Published

2019

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)