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Booster vaccination in the elderly: Their success depends on the vaccine type applied earlier in life as well as on pre-vaccination antibody titers by Maria Kaml; Ilka Weiskirchner; Michael Keller; Thomas Luft; Eva Hoster; Joerg Hasford; Linda Young; Bill Bartlett; Christoph Neuner; Karl-Heinz Fischer; Ber Neuman; Reinhard Würzner; Beatrix Grubeck-Loebenstein is a Medicine article available to read on EtoBox.
What is Booster vaccination in the elderly: Their success depends on the vaccine type applied earlier in life as well as on pre-vaccination antibody titers about?
Background Recent retrospective studies demonstrate that elderly persons have a shortened protection period following vaccination with recall antigens. Methods We now analysed the effect of booster vaccination with a multivalent vaccine containing tetanus, dipththeria, pertussis and polio antigens in 252 healthy elderly persons. The magnitude of the humoral immune response was assessed by antibody measurements. Results Comparison with a small control group of 21 younger persons demonstrates that pre- and post-vaccination antibody concentrations are lower in elderly persons for all antigens except polio, for which higher pre- and similar post-vaccination antibody levels are observed. Using multiple linear regression analysis we also show that the magnitude of the humoral immune response in elderly persons greatly depends on pre-vaccination antibody concentrations in the case of tetanus, diphtheria and pertussis, but much less so in the case of polio, against which priming and preceding booster immunizations were performed with attenuated live vaccine. Conclusion Regular booster vaccinations throughout life are of clinical importance to maintain the ability to respond to recall antig
Who reads Booster vaccination in the elderly: Their success depends on the vaccine type applied earlier in life as well as on pre-vaccination antibody titers?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Maria Kaml; Ilka Weiskirchner; Michael Keller; Thomas Luft; Eva Hoster; Joerg Hasford; Linda Young; Bill Bartlett; Christoph Neuner; Karl-Heinz Fischer; Ber Neuman; Reinhard Würzner; Beatrix Grubeck-Loebenstein
- Publisher
- Elsevier BV
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)