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MR microscopy of lung airways with hyperpolarized ^3^He by X. Josette Chen; Mark S. Chawla; Laurence W. Hedlund; Harald E. Möller; James R. Macfall; G. Allan Johnson; Elaine G. is a Medicine article available to read on EtoBox.

What is MR microscopy of lung airways with hyperpolarized ^3^He about?

## Abstract A technique using hyperpolarized (HP) ^3^He to image the small airways of the lung by using moderate flip angles and a short scanning period during early inspiration is demonstrated. Flip angles __(α)__ ranging from 10–90° were used in guinea pig experiments with scanning during the entire inspiration period. A second series acquired data throughout a short window of the ventilatory cycle with α= 45°. The success of the animal studies has motivated implementation of similar imaging techniques in the clinical arena. Human studies involved imaging over the total inspiration period with __α ≈︁__ 10°. The first series of guinea pig experiments demonstrated that larger flip angles (50‐90°) destroy the magnetization before it reaches the smaller airways. At moderate flip angles (20‐40°), airway branching down to the fourth generation was apparent. Fifth‐order branchings were seen in the images of the second series. The trachea down to fourth generation pulmonary airway branching, along with some distal air spaces, was seen in the human lung images.

Who reads MR microscopy of lung airways with hyperpolarized ^3^He?

Author

X. Josette Chen; Mark S. Chawla; Laurence W. Hedlund; Harald E. Möller; James R. Macfall; G. Allan Johnson; Elaine G.

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

1998

Language

EN

Field

Medicine (Health Sciences)