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Foetal Fluid Balance And Hormone Status Following Nephrectomy In The Foetal Sheep by Karen M Moritz; Mary Macris; Gert Talbo; E Marelyn Wintour is a Medicine article available to read on EtoBox.

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## SUMMARY 1. The role of the kidneys in the maintenance of normal foetal plasma (FP) composition and hormone concentrations was examined in the present study. Five ovine foetuses were chronically cannulated and nephrectomized (nephx) at 100±1 days of gestation and maintained for 14 days. These were compared to five intact control foetuses. 2. Four hours after nephx, FP renin concentrations were significantly lower than in control foetuses. By 48 h, renin concentrations in nephx foetuses were below the level of detectability of the assay. Foetal plasma aldosterone concentrations declined in nephx foetuses, but were not significantly different to those in control foetuses (__P__ = 0.08). 3. During the second week, the nephx foetuses were significantly hypoxic, but FP erythropoietin concentrations were not increased. Adrenocorticotropic hormone (ACTH) and cortisol concentrations, when measured on day 14, were not different between the two groups. Adrenocorticotropic hormone levels were correlated with adrenal weight at post‐mortem. 4. Foetal plasma creatinine, magnesium and phosphate concentrations in nephx foetuses increased, eventually reaching values approximately twice that in co

Who reads Foetal Fluid Balance And Hormone Status Following Nephrectomy In The Foetal Sheep?

Author

Karen M Moritz; Mary Macris; Gert Talbo; E Marelyn Wintour

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0305-1870)

Published

1999

Language

EN

Field

Medicine (Health Sciences)