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Transforming growth factor alpha and CD68 immunoreactivity in giant cell tumours of bone: A study on the nature of stromal and giant cells, and their interrelations by Tadashi Hasegawa; Takanori Hirose; Kunihiko Seki; Toshiaki Sano; Kazuo Hizawa is a Medicine article available to read on EtoBox.

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## Abstract To clarify the nature of neoplastic cells, 17 giant cell tumours of bone were studied histologically and immunohisto‐chemically. L1 antigen and S‐100 protein were not detected in the tumour giant cells and stromal cells, although present in non‐neoplastic macrophages. The giant cells in all the lesions, some stromal cells, and osteoclasts in the normal bone showed CD68 and transforming growth factor alpha (TGFα) immunoreactivity. Fibrohistiocytic antigen, factor XIIIa, was expressed in large numbers of stromal cells in all lesions. Some stromal cells expressed α‐smooth muscle actin and osteocalcin. These immunohistochemical results suggested that the stromal cells of giant cell tumours of bone showed histiocytic and occasional myofibroblastic and osteoblastic differentiation. Proliferating cell nuclear antigen was demonstrated in the nuclei of the stromal cells only, indicating that these were the sole proliferating elements. TGFα produced by the giant cells and some stromal cells may play a role as a mediator for the attraction and/or proliferation of the precursor cells, and may suppress the activity of osteoblastic stromal cells, resulting in restricted bone formatio

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Author

Tadashi Hasegawa; Takanori Hirose; Kunihiko Seki; Toshiaki Sano; Kazuo Hizawa

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

1993

Language

EN

Field

Medicine (Health Sciences)