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Anti-adipogenic effect of PDGF is reversed by PKC inhibition by Y. Artemenko; A. Gagnon; D. Aubin; A. Sorisky is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Healthy adipose tissue function depends on adipogenesis. The capacity to form new adipocytes prevents the emergence of insulin‐resistant hypertrophied adipocytes, as well as the deleterious lipid deposition in muscle, liver, and pancreas. It is therefore important to understand how adipogenesis is modulated. Platelet‐derived growth factor (PDGF) is anti‐adipogenic, but the stage of differentiation that it targets, and the signaling pathways that it triggers, are not defined. We have studied the inhibitory effect of PDGF on murine 3T3‐L1 preadipocyte and human preadipocyte differentiation. There was a significant attenuation in the protein expression of the adipogenic transcription factors, PPARγ and C/EBPα, as well as in the levels of later differentiation markers, including adiponectin, aP2, and fatty acid synthase. PDGF treatment resulted in the persistence of PDGF receptor and PKCα expression, in contrast to the expected downregulation of both proteins that occurs during differentiation. Inactivation of conventional PKC isoforms, by bisindolylmaleimide I or PKC pseudosubstrate M20–28, partially reversed the inhibition of 3T3‐L1 and human preadipocyte differentiation

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Author

Y. Artemenko; A. Gagnon; D. Aubin; A. Sorisky

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)

Published

2005

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)