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Tendon-bioinspired Wavy Nanofibrous Scaffolds Provide Tunable Anisotropy and Promote Tenogenesis for Tendon Tissue Engineering by Shaohua Wu; Jiao Liu; Ye Qi; Jiangyu Cai; Jinzhong Zhao; Bin Duan; Shaojuan Chen is a Engineering article available to read on EtoBox.

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The development of tendon-biomimetic nanofibrous scaffolds with mesenchymal stem cells may represent a promising strategy to improve the unsatisfactory outcomes of traditional treatments in tendon repair. In the present study, the nanofibrous scaffolds comprised of poly(p-dioxanone) (PPDO) and silk fibroin (SF) composites were fabricated by using electrospinning technique and subsequent thermal ethanol treatment. The PPDO/SF composite scaffolds presented parallel fiber arrangement with crimped features and nonlinear mechanical properties, which mimic the structure-function relationship of native tendon tissue mechanics. We demonstrated that the fiber crimp degree and mechanical properties of as-prepared PPDO/SF wavy nanofibrous scaffolds (WNSs) could be tunable by adjusting the mass ratio of PPDO/SF. The biological tests revealed that the addition of SF obviously promoted the cell adhesion, proliferation, and phenotypic maintenance of human tenocytes on the WNSs. A preliminary study on the subcutaneous implantation showed that the PPDO/SF WNSs notably decreased the inflammatory response compared with pure PPDO WNSs. More importantly, a combination of growth factor induction and mec

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Author

Shaohua Wu; Jiao Liu; Ye Qi; Jiangyu Cai; Jinzhong Zhao; Bin Duan; Shaojuan Chen

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Engineering (Physical Sciences)