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Highly Efficient Epoxidation of Unsaturated Steroids Using Magnesium Bis(monoperoxyphthalate) Hexahydrate by João F.S. Carvalho; M. Manuel Cruz Silva; M. Luisa Sá e Melo is a Chemistry article available to read on EtoBox.

What is Highly Efficient Epoxidation of Unsaturated Steroids Using Magnesium Bis(monoperoxyphthalate) Hexahydrate about?

Fast generation of epoxides from the corresponding homoallylic and allylic steroidal olefins was developed by using magnesium bis(monoperoxyphthalate) hexahydrate (MMPP) as oxidant suspended in acetonitrile (CH 3 CN) at reflux temperature. The protocol involves the use of a safe readily available oxidant along with an easy work-up, which renders the process very efficient. Selective 4,5-and 5,6epoxidations of steroids are reported. Among them, highly stereoselective epoxidation of D 5 -B-norcholestanes was achieved. Moreover, the method is chemoselective for the 5,6-position and can be applied to the epoxidation of ring-A enones.

Who reads Highly Efficient Epoxidation of Unsaturated Steroids Using Magnesium Bis(monoperoxyphthalate) Hexahydrate?

Author

João F.S. Carvalho; M. Manuel Cruz Silva; M. Luisa Sá e Melo

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4020)

Published

2009

Language

EN

Field

Chemistry (Physical Sciences)