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Improved synthesis and low-temperature autoradiographic evaluation of 18F-n-fluoropropane as a myelin tracer for positron emission tomography by Mirko Diksic; Balashandran Kodery; Kazuhiro Sako; William Feindel; Y. Lucas Yamamoto is a Medicine article available to read on EtoBox.
What is Improved synthesis and low-temperature autoradiographic evaluation of 18F-n-fluoropropane as a myelin tracer for positron emission tomography about?
An improved synthesis of the lipophile 18F-fluoropropane, yielding 30-45 mCi 18F-labelled radiopharmaceutical, is described. The radiochemical yield was 55%-66% determined at the end of a 1-h synthesis. Radiochemical and chemical purity of 18F-fluoropropane was 99% as determined by gas chromatography. Low-temperature autoradiography was used to investigate the lipophile 18F-n-fluoropropane as a myelin tracer for use with positron emission tomography. The white to grey matter ratio based on autoradiograms 12 min after administration of the radiotracer was 2:1, the highest reported to date.
Who reads Improved synthesis and low-temperature autoradiographic evaluation of 18F-n-fluoropropane as a myelin tracer for positron emission tomography?
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- Author
- Mirko Diksic; Balashandran Kodery; Kazuhiro Sako; William Feindel; Y. Lucas Yamamoto
- Publisher
- Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0340-6997)
- Published
- 1983
- Language
- EN
- Field
- Medicine (Health Sciences)