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Reconstitution of the actin-scavenger system after orthotopic liver transplantation for end-stage liver disease: A prospective and longitudinal study by Schiødt, Frank Vinholt ;Bondesen, Stig ;Müller, Klaus ;Rasmussen, Allan ;Hjortrup, Allan ;Kirkegaard, Preben ;Hansen, Bent Adel ;Tygstrup, Niels ;Ott, Peter is a Medicine article available to read on EtoBox.

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Serum levels of the actin scavenger Gc-globulin (group-specific component, vitamin D-binding protein), a member of the albumin multigene family, are decreased in severe liver disease but have not been evaluated in relation to liver transplantation. We measured Gc-globulin and Gcglobulin-actin complex ratio daily for 2 weeks after transplantation in 17 patients with end-stage liver disease. Before transplantation, Gc-globulin levels were significantly less in the patients than in healthy controls (235 ؎ 106 v 340 ؎ 35 mg/L, respectively; PF .001), whereas complex ratio level was in the normal range. Five patients (group N) had pretransplantation Gc-globulin values within the normal range (mean ؎ 2 SD), and 12 patients had subnormal values (group S). In group N, mean Gc-globulin levels posttransplantation remained stable at a lower level than before transplantation but still within normal range. In this group, cold ischemia time correlated inversely with Gc-globulin levels on day 2 (r ‫؍‬ -0.88; P F .05). In group S, normal mean levels were reached at a mean of 11 days after transplantation. However, almost half these patients had subnormal Gc-globulin levels at day 14. Complex ratio

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Author

Schiødt, Frank Vinholt ;Bondesen, Stig ;Müller, Klaus ;Rasmussen, Allan ;Hjortrup, Allan ;Kirkegaard, Preben ;Hansen, Bent Adel ;Tygstrup, Niels ;Ott, Peter

Publisher

Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1074-3022)

Published

1999

Language

EN

Field

Medicine (Health Sciences)