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Scalable plasma and digital cognitive markers for diagnosis and prognosis of Alzheimer's disease and related dementias by Elena Tsoy; Renaud La Joie; Lawren VandeVrede; Julio C. Rojas; Claire Yballa; Brandon Chan; Argentina Lario Lago; Anne‐Marie Rodriguez; Collette A. Goode; Sabrina J. Erlhoff; Boon Lead Tee; Charles Windon; Serggio Lanata; Joel H. Kramer; Bruce L. Miller; Peggye Dilworth‐Anderson; Adam L. Boxer; Gil D. Rabinovici; Katherine L. Possin is a Medicine article available to read on EtoBox.

What is Scalable plasma and digital cognitive markers for diagnosis and prognosis of Alzheimer's disease and related dementias about?

## Abstract ## INTRODUCTION With emergence of disease‐modifying therapies, efficient diagnostic pathways are critically needed to identify treatment candidates, evaluate disease severity, and support prognosis. A combination of plasma biomarkers and brief digital cognitive assessments could provide a scalable alternative to current diagnostic work‐up. ## METHODS We examined the accuracy of plasma biomarkers and a 10‐minute supervised tablet‐based cognitive assessment (Tablet‐based Cognitive Assessment Tool Brain Health Assessment [TabCAT‐BHA]) in predicting amyloid β positive (Aβ+) status on positron emission tomography (PET), concurrent disease severity, and functional decline in 309 older adults with subjective cognitive impairment (__n__ = 49), mild cognitive impairment (__n__ = 159), and dementia (__n__ = 101). ## RESULTS Combination of plasma pTau181, Aβ42/40, neurofilament light (NfL), and TabCAT‐BHA was optimal for predicting Aβ‐PET positivity (AUC = 0.962). Whereas NfL and TabCAT‐BHA optimally predicted concurrent disease severity, combining these with pTau181 and glial fibrillary acidic protein was most accurate in predicting functional decline. ## DISCUSSION Combinations

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Author

Elena Tsoy; Renaud La Joie; Lawren VandeVrede; Julio C. Rojas; Claire Yballa; Brandon Chan; Argentina Lario Lago; Anne‐Marie Rodriguez; Collette A. Goode; Sabrina J. Erlhoff; Boon Lead Tee; Charles Windon; Serggio Lanata; Joel H. Kramer; Bruce L. Miller; Peggye Dilworth‐Anderson; Adam L. Boxer; Gil D. Rabinovici; Katherine L. Possin

Publisher

John Wiley and Sons Inc.

Published

2024

Language

EN

Field

Medicine (Health Sciences)