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Activity of tannins from Stryphnodendron adstringens on Cryptococcus neoformans: effects on growth, capsule size and pigmentation by Kelly Ishida; Sonia Rozental; João Carlos Palazzo de Mello; Celso Vataru Nakamura is a Medicine article available to read on EtoBox.
What is Activity of tannins from Stryphnodendron adstringens on Cryptococcus neoformans: effects on growth, capsule size and pigmentation about?
## Abstract ## Background __Stryphnodendron adstringens__ (Mart.) Coville, Leguminosae, also known in Brazil as barbatimão, is rich in tannins and many flavan-3-ols and proanthocyanidins such as prodelphinidins and prorobinetinidins. Previous studies have demonstrated several pharmacological properties of tannins from barbatimão, including anti-candidal activity. ## Methods The antifungal activity of proanthocyanidin polymeric tannins from __Stryphnodendron adstringens__ (subfraction F2.4) was evaluated against three strains of __Cryptococcus neoformans__ with different capsule expressions, using the broth microdilution technique, light microscopy and transmission electron microscopy. The effect of subfraction F2.4 on __C. neoformans__ and melanoma mammalian cells pigmentation was also evaluated. ## Results Although susceptibility assays revealed MIC values quite similar (between 2.5 and 5.0 μg/ml), analyses of MFC values revealing that the acapsular mutant Cap 67 was more susceptible to be killed by the subfraction F2.4 (MFC = 20 μg/ml) than the two tested capsular strains (T~1~-444 and ATCC 28957) (MFC > 160 μg/ml). Optical and electron microscopy experiments revealed relevant al
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- Author
- Kelly Ishida; Sonia Rozental; João Carlos Palazzo de Mello; Celso Vataru Nakamura
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2002]-; Springer Science and Business Media LLC; Springer Nature (ISSN 1476-0711)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)