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Evaluation of primary HPV-DNA testing in relation to visual inspection methods for cervical cancer screening in rural China: an epidemiologic and cost-effectiveness modelling study by Ju-Fang Shi; Karen Canfell; Jie-Bin Lew; Fang-Hui Zhao; Rosa Legood; Yan Ning; Leonardo Simonella; Li Ma; Yoon-Jung Kang; Yong-Zhen Zhang; Megan A Smith; Jun-Feng Chen; Xiang-Xian Feng; You-Lin Qiao is a Medicine article available to read on EtoBox.

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## Background A new lower-cost rapid-throughput human papillomavirus (HPV) test (__care__HPV, Qiagen, Gaithersburg, USA) has been shown to have high sensitivity for the detection of high grade cervical intraepithelial neoplasia. ## Methods We assessed the outcomes and cost-effectiveness of __care__HPV screening in rural China, compared to visual inspection with acetic acid, when used alone (VIA) or in combination with Lugol's iodine (VIA/VILI). Using data on sexual behaviour, test accuracy, diagnostic practices and costs from studies performed in rural China, we estimated the cost-effectiveness ratio (CER) and associated lifetime outcomes for once-lifetime and twice-lifetime screening strategies, and for routine screening at 5-yearly, 10-yearly and IARC-recommended intervals. The optimal age range for once-lifetime screening was also assessed. ## Results For all strategies, the relative ordering of test technologies in reducing cervical cancer incidence and mortality was VIA (least effective); VIA/VILI; [email protected] pg/ml and [email protected] pg/ml (most effective). For once-lifetime strategies, maximum effectiveness was achieved if screening occurred between 35-50 years. Assumin

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Author

Ju-Fang Shi; Karen Canfell; Jie-Bin Lew; Fang-Hui Zhao; Rosa Legood; Yan Ning; Leonardo Simonella; Li Ma; Yoon-Jung Kang; Yong-Zhen Zhang; Megan A Smith; Jun-Feng Chen; Xiang-Xian Feng; You-Lin Qiao

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2001]-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2407)

Published

2011

Language

EN

ISBN

9781471240713

Field

Medicine (Health Sciences)