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Can I read Gata-3 and KI-67 expression in correlation with molecular subtypes of breast cancer on EtoBox?
Gata-3 and KI-67 expression in correlation with molecular subtypes of breast cancer by M. Husni Cangara; Upik A. Miskad; Rina Masadah; Berti J. Nelwan; Syarifuddin Wahid is a Medicine article available to read on EtoBox.
What is Gata-3 and KI-67 expression in correlation with molecular subtypes of breast cancer about?
OBJECTIVES: This study aims to evaluate and compare four breast cancer subtypes defined by immunohistochemistry expression of ER, PR, and HER-2 in correlation with Ki-67 and GATA-3 expression. METHODS: Slides from 89 paraffin blocks of invasive breast cancer patients with four molecular subtypes based on HER-2, ER, and PR expression were then stained with Ki-67 and GATA-3 antibodies to evaluate their expression in correlation with molecular subtype and metastases to lymph nodes. RESULTS: This study was a retrospective study of 89 invasive breast cancers. Luminal A; Luminal B; HER2+; and triple-negative types were 35 (39.3%), 10 (11.2%), 27 (30.3%), and 17 (19.1%) samples. Expression of Ki-67 was increased in triple-negative (TN) tumor compared to non-triple-negative (non-TN) tumor subtypes (p < 0.05). This Ki-67 expression was inversely correlated with the positivity of hormone receptor expression related to lymph-node metastases in TN-type tumors. Sixty-two (57%) samples were immunohistochemically positive for GATA-3. GATA-3 positive samples were significantly more likely to be ER and PR-positive, Ki-67 negative, and luminal A tumors. CONCLUSIONS: Subtype triple-negative breast ca
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- Author
- M. Husni Cangara; Upik A. Miskad; Rina Masadah; Berti J. Nelwan; Syarifuddin Wahid
- Publisher
- IOS Press
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)