Can I read Preventive HIPEC in combination with perioperative FLOT versus FLOT alone for resectable diffuse type gastric and gastroesophageal junction type II/III adenocarcinoma – the phase III “PREVENT”- (FLOT9) trial of the AIO /CAOGI /ACO on EtoBox?

Preventive HIPEC in combination with perioperative FLOT versus FLOT alone for resectable diffuse type gastric and gastroesophageal junction type II/III adenocarcinoma – the phase III “PREVENT”- (FLOT9) trial of the AIO /CAOGI /ACO by Thorsten O. Götze; Pompiliu Piso; Sylvie Lorenzen; Ulli S. Bankstahl; Claudia Pauligk; Moustafa Elshafei; Giuseppe Amato; Daniel Reim; Wolf O. Bechstein; Alfred Königsrainer; Stefan P. Mönig; Beate Rau; Matthias Schwarzbach; Salah-Eddin Al-Batran is a Medicine article available to read on EtoBox.

What is Preventive HIPEC in combination with perioperative FLOT versus FLOT alone for resectable diffuse type gastric and gastroesophageal junction type II/III adenocarcinoma – the phase III “PREVENT”- (FLOT9) trial of the AIO /CAOGI /ACO about?

## Abstract ## Background The main reason for treatment failure after curative surgical resection of gastric cancer is intra-abdominal spread, with 40–50% peritoneal seeding as primary localization of recurrence. Peritoneal relapse is seen in 60–70% of tumors of diffuse type, compared to only 20–30% of intestinal type. Hyperthermic IntraPEritoneal Chemoperfusion (HIPEC) is an increasingly used therapy method for patients with peritoneal metastases. The preventive use of HIPEC could represent an elegant approach for patients (pts) before macroscopic peritoneal seeding, since pts. with operable disease are fit and may have potential risk of microscopic involvement, thus having a theoretical chance of cure with HIPEC even without the need for cytoreduction. No results from a PCRT from the Western hemisphere have yet been published. ## Methods This is a multicenter, randomized, controlled, open-label study including a total of 200 pts. with localized and locally advanced diffuse or mixed type (Laurens’s classification) adenocarcinoma of the stomach and Type II/III GEJ. All enrolled pts. will have received 3–6 pre-operative cycles of biweekly FLOT (Docetaxel 50 mg/m^2^; Oxaliplatin 85 m

Who reads Preventive HIPEC in combination with perioperative FLOT versus FLOT alone for resectable diffuse type gastric and gastroesophageal junction type II/III adenocarcinoma – the phase III “PREVENT”- (FLOT9) trial of the AIO /CAOGI /ACO?

Author

Thorsten O. Götze; Pompiliu Piso; Sylvie Lorenzen; Ulli S. Bankstahl; Claudia Pauligk; Moustafa Elshafei; Giuseppe Amato; Daniel Reim; Wolf O. Bechstein; Alfred Königsrainer; Stefan P. Mönig; Beate Rau; Matthias Schwarzbach; Salah-Eddin Al-Batran

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)