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A Blend Hydrogel Based on Polyoxometalate for Long-term and Repeatedly Localized Antibacterial Application Study by Yan Fang; Taiyu Liu; Cuili Xing; Jiangnan Chang; Mingxue Li is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

What is A Blend Hydrogel Based on Polyoxometalate for Long-term and Repeatedly Localized Antibacterial Application Study about?

Herein, a polyoxometalate (POM)-based blend hydrogel system was in situ constructed by incorporating cetyltrimethylammoniumbromide (CTAB)-encapsulated POM cationic micelles to bare hydrogel matrixes followed by copolymerization of multivalent crosslinking groups. It was demonstrated that the fabricated blend hydrogel possessed tunable physicochemical properties, good swelling behavior (maximum swelling rate of 229% in buffer solution of pH 8.0), excellent local action and sustained release of POM component (release ratio achieved nearly 100% at the time of 120 min). Antibacterial activity study revealed that the introduction of POM greatly improved the bioavailability of itself, namely, leading to a more effective enhancement of therapeutic effects (survival ratio of both strains less than 5%). Besides, bactericidal rates (ca. 51%) were achieved even after six runs repeated, thereby verifying the biological application potential of this material. Finally, the practical application potentials were investigated and future prospects in relevant research areas were forecasted.

Who reads A Blend Hydrogel Based on Polyoxometalate for Long-term and Repeatedly Localized Antibacterial Application Study?

Author

Yan Fang; Taiyu Liu; Cuili Xing; Jiangnan Chang; Mingxue Li

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2020

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)