Can I read Bolus-tracking MRI with a simultaneous T1- and T-measurement on EtoBox?

Bolus-tracking MRI with a simultaneous T1- and T-measurement by S. Sourbron; M. Heilmann; A. Biffar; C. Walczak; J. Vautier; A. Volk; M. Peller is a Medicine article available to read on EtoBox.

What is Bolus-tracking MRI with a simultaneous T1- and T-measurement about?

## Abstract The aim of this study was to propose and evaluate a methodology to analyze simultaneously acquired __T__‐weighted dynamic susceptibility contrast (DSC) MRI and __T__~1~‐weighted dynamic contrast enhanced (DCE) MRI data. Two generalized models of __T__‐relaxation are proposed to account for tracer leakage, and a two‐compartment exchange model is used to separate tracer in intra‐ and extravascular spaces. The methods are evaluated using data extracted from ROIs in three mice with subcutaneously implanted human colorectal tumors. Comparing plasma flow values obtained from DCE‐MRI and DSC‐MRI data defines a practical experimental paradigm to measure __T__‐relaxivities, and reveals a factor of 15 between values in tissue and blood. Comparing mean transit time values obtained from DCE‐MRI and DSC‐MRI without leakage correction, indicates a significant reduction of susceptibility weighting in DSC‐MRI during tracer leakage. A one‐parameter gradient correction model provides a good approximation for this susceptibility loss, but redundancy of the parameter limits the practical potential of this model for DSC‐MRI. Susceptibility loss is modeled more accurately with a variable __T

Who reads Bolus-tracking MRI with a simultaneous T1- and T-measurement?

Author

S. Sourbron; M. Heilmann; A. Biffar; C. Walczak; J. Vautier; A. Volk; M. Peller

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

2009

Language

EN

Field

Medicine (Health Sciences)