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Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta by Simon Gibbons; Fatemeh Fallah; Colin W. Wright is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract The activity of cryptolepine hydrochloride, a salt of the main indoloquinoline alkaloid from the West African medicinal plant __Cryptolepis sanguinolenta__, was assessed against the fast growing mycobacterial species __Mycobacterium fortuitum__, which has recently been shown to be of use in the evaluation of antitubercular drugs. The low minimum inhibitory concentration (MIC) of this compound (16 μg/mL) prompted further evaluation against other fast growing mycobacteria namely, __M. phlei__, __M. aurum__, __M. smegmatis__, __M. bovis__ BCG and __M. abcessus__ and the MICs ranged over 2–32 μg/mL for these species. The strong activity of this agent, the need for new antibiotics with activity against __Mycobacterium tuberculosis__, coupled with the ethnobotanical use of __C. sanguinolenta__ extracts to treat infections, highlight the potential of the cryptolepine template for development of antimycobacterial agents. Copyright © 2003 John Wiley & Sons, Ltd.

Who reads Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta?

Author

Simon Gibbons; Fatemeh Fallah; Colin W. Wright

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-418X)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)