About this Agricultural and Biological Sciences article

Effect of Lycopene Supplementation on Cardiovascular Parameters and Markers of Inflammation and Oxidation in Patients with Coronary Vascular Disease by Ivan M. Petyaev; Pavel Y. Dovgalevsky; Victor A. Klochkov; Natalya E. Chalyk; Dmitry V. Pristensky; Marina P. Chernyshova; Ruzan Udumyan; Taron Kocharyan; Nigel H. Kyle; Marina V. Lozbiakova; Yuriy K. Bashmakov is a Agricultural and Biological Sciences article available to read on EtoBox.

Oxidative stress and antioxidant deficiency play a pivotal role in initiation, development, and outcomes of cardiovascular disease. Pharmacokinetic parameters as well as the impact of highly bioavailable lycopene on cardiovascular variables, markers of inflammation and oxidation were investigated during a 30-day clinical trial in patients with coronary vascular disease. The patients were randomized into two major groups and were supplemented with a single 7 mg daily dose of lycopene ingested either in the form of lactolycopene (68 patients) or in the form of lycosome-formulated GA lycopene (74 patients). The endpoints included cardiovascular function parameters, serum lipids, and four markers of oxidative stress and inflammation. Ingestion of lycosome-formulated lycopene increased serum lycopene levels by 2.9- and 4.3-fold, respectively, after 2 and 4 weeks of the trial, whereas supplementation with lactolycopene upregulated serum lycopene by half-fold only after 4 weeks of ingestion. Lycosome formulation of lycopene resulted by the end of the trial in a threefold reduction in IgG and reduction to the same degree of the inflammatory oxidative damage marker. The decrease in oxidized

Author

Ivan M. Petyaev; Pavel Y. Dovgalevsky; Victor A. Klochkov; Natalya E. Chalyk; Dmitry V. Pristensky; Marina P. Chernyshova; Ruzan Udumyan; Taron Kocharyan; Nigel H. Kyle; Marina V. Lozbiakova; Yuriy K. Bashmakov

Published

2018

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)