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Can I read In vivo dissolution of poorly water-soluble drugs: Proof of concept based on fluorescence bioimaging on EtoBox?
In vivo dissolution of poorly water-soluble drugs: Proof of concept based on fluorescence bioimaging by Yinqian Yang; Yongjiu Lv; Chengying Shen; Tingting Shi; Haisheng He; Jianping Qi; Xiaochun Dong; Weili Zhao; Yi Lu; Wei Wu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is In vivo dissolution of poorly water-soluble drugs: Proof of concept based on fluorescence bioimaging about?
__In vitro__‒__in vivo__ correlation (IVIVC) of solid dosage forms should be established basically between __in vitro__ and __in vivo__ dissolution of active pharmaceutical ingredients. Nevertheless, __in vivo__ dissolution profiles have never been accurately portrayed. The current practice of IVIVC has to resort to __in vivo__ absorption fractions (__F__~a~). In this proof-of-concept study, __in vivo__ dissolution of a model poorly water-soluble drug fenofibrate (FNB) was investigated by fluorescence bioimaging. FNB crystals were first labeled by near-infrared fluorophores with aggregation-caused quenching properties. The dyes illuminated FNB crystals but quenched immediately and absolutely once been released into aqueous media, enabling accurate monitoring of residual drug crystals. The linearity established between fluorescence and crystal concentration justified reliable quantification of FNB crystals. __In vitro__ dissolution was first measured following pharmacopoeia monograph protocols with well-documented IVIVC. The synchronicity between fluorescence and __in vitro__ dissolution of FNB supported using fluorescence as a measure for determination of dissolution. __In vitro__
Who reads In vivo dissolution of poorly water-soluble drugs: Proof of concept based on fluorescence bioimaging?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yinqian Yang; Yongjiu Lv; Chengying Shen; Tingting Shi; Haisheng He; Jianping Qi; Xiaochun Dong; Weili Zhao; Yi Lu; Wei Wu
- Publisher
- Elsevier ; Elsevier BV; Amsterdam: Elsevier (ISSN 2211-3835)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)