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IL-12 and IFN-γ production, and NK cell activity, in acute and chronic experimental Trypanosoma cruzi infections by Marı́a Inés Antúnez; Rita L. Cardoni is a Immunology and Microbiology article available to read on EtoBox.

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Resistance to acute Trypanosoma cruzi infection is mainly associated with a Th1 immune response, characterized by gamma-interferon (IFN-g) production and activation of macrophages. The outcome of the Th1 response in the spleen and serum of BALB/c and C3H mice infected with T. cruzi, Tulahue ́n strain was studied. The levels of interleukin-12 p40 (IL-12 p40) and IFN-g, as well as natural killer (NK) cell cytotoxicity were determined at different time-points during the acute phase, and the production of cytokines was also studied in the chronic infection. At 2 days post-infection (pi), spleen cells from C3H mice increased their NK cell activity and the ex vivo spontaneous release of both IL-12 p40 and IFN-g. On the other hand, BALB/c mice reached low levels of NK cell cytotoxicity and no IFN-g production was detected at this time pi, but the cytokine was released at high amounts in the second week of the infection. Seric IL-12 p40 concentrations showed a 3-fold increase in both mouse strains on the second day pi and remained high throughout the acute phase. However, seric IFN-g levels increased during the late acute infection and were higher in BALB/c than in C3H mice. In chronicall

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Author

Marı́a Inés Antúnez; Rita L. Cardoni

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0165-2478)

Published

2000

Language

EN

Field

Immunology and Microbiology (Life Sciences)