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Ultrasound Responsive Magnetic Mesoporous Silica Nanoparticle-Loaded Microbubbles for Efficient Gene Delivery by Du, Meng; Chen, Yuhao; Tu, Jiawei; Liufu, Chun; Yu, Jinsui; Yuan, Zhen; Gong, Xiaojing; Chen, ZhiYi is a Engineering article available to read on EtoBox.
What is Ultrasound Responsive Magnetic Mesoporous Silica Nanoparticle-Loaded Microbubbles for Efficient Gene Delivery about?
: Gene therapy is an important therapeutic strategy for cancer. Nanoparticles are used for noninvasive gene delivery, which has great potential in tumor therapy. However, it is a challenge to construct a targeted gene delivery vector with high gene delivery efficiency, good biocompatibility, and multiple functions. : Herein, we designed magnetic mesoporous silica nanoparticle loading microbubbles (M-MSN@MBs) for ultrasound-mediated imaging and gene transfection. The plasmid DNA (pDNA) was encapsulated into the pores of M-MSNs. Also, the pDNA-carrying M-MSNs were loaded in the lipid microbubbles. : The gene vector presented good biocompatibility, DNA binding stability, ultrasound imaging performance, and magnetic responsiveness. The polyethyleneimine (PEI)-modified M-MSNs effectively protected the loaded pDNA from enzyme degradation. The cytotoxicity of M-MSNs was significantly reduced via encapsulating in lipid microbubbles. Upon the magnetic field, M-MSN@MBs were attracted to the tumor area. Then, ultrasound-targeted microbubble destruction (UTMD) not only released loaded M-MSNs but also facilitated M-MSNs delivery to tumor tissue by opening blood-tumor barrier and increasing the
Who reads Ultrasound Responsive Magnetic Mesoporous Silica Nanoparticle-Loaded Microbubbles for Efficient Gene Delivery?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Du, Meng; Chen, Yuhao; Tu, Jiawei; Liufu, Chun; Yu, Jinsui; Yuan, Zhen; Gong, Xiaojing; Chen, ZhiYi
- Publisher
- American Chemical Society; American Chemical Society (ACS) (ISSN 2373-9878)
- Published
- 2020
- Language
- EN
- Field
- Engineering (Physical Sciences)