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Heterogeneity of the Human H Blood Group α (1,2) Fucosyltransferase Gene among Para-Bombay Individuals by Lung-Chih Yu; Yun-Hsin Yang; Richard E. Broadberry; Yee-Hsiung Chen; Marie Lin is a Medicine article available to read on EtoBox.

What is Heterogeneity of the Human H Blood Group α (1,2) Fucosyltransferase Gene among Para-Bombay Individuals about?

## Abstract Background and objectives: The para‐Bombay phenotype has a relatively high frequency of about 1 in 8,000 Taiwanese. Studies were carried out on eight healthy and unrelated Taiwanese with the para‐Bombay phenotype to cast light on its immunogenetic basis. Materials and methods: Blood and saliva samples were tested with standard hemagglutination techniques. Salivary ABH substances were determined by hemagglutination inhibition. PCR techniques were used to amplify the coding region of the __H__ genes. Results: Five different __h__ alleles, designated as __h1, h2, h3, h4__ and __h5,__ were identified in the Taiwanese with the para‐Bombay phenotype. The __h1__ allele loses one of the three AG repeats located at the nucleotides 547–552 of the __H__ gene, whereas two of the three T repeats located at the nucleotides 880–882 are deleted in the __h2__ allele. The __h3__ allele contains a C^658^ to T missense mutation, whereas two missense mutations, C^35^ to T and A^980^ to C were identified in the __h4__ allele. A T^460^ to C missense is present in the __h5__allele. The __h5__ allele was identified in an individual whose red blood cells contain blood group A antigen but not H

Who reads Heterogeneity of the Human H Blood Group α (1,2) Fucosyltransferase Gene among Para-Bombay Individuals?

Author

Lung-Chih Yu; Yun-Hsin Yang; Richard E. Broadberry; Yee-Hsiung Chen; Marie Lin

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0042-9007)

Published

1997

Language

EN

Field

Medicine (Health Sciences)