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Antitubercular Pyridine Analogs Synthesis by Ish Kat is a document available to read on EtoBox.
The study focuses on the synthesis of isoniazid and pyridine derivatives to combat multi-drug resistant Mycobacterium tuberculosis (MDR-MTB). Compounds 1 and 2 exhibited significant anti-mycobacterial activity with IC50 values of 3.2 µM and 1.5 µM, respectively, against the H37Rv strain, as well as promising efficacy against various drug-resistant isolates. The findings highlight the potential of these new analogs in addressing the urgent need for effective treatments against drug-resistant tuberculosis.
- Author
- Ish Kat
- Language
- EN