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Wilson's Disease Tremor Is Associated with Magnetic Resonance Imaging Lesions in Basal Ganglia Structures by Martin Südmeyer; Andreas Saleh; Lars Wojtecki; Mathias Cohnen; Joachim Gross; Markus Ploner; Harald Hefter; Lars Timmermann; Alfons Schnitzler is a Medicine article available to read on EtoBox.
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## Abstract Wilson's disease (WD) is an inherited disorder of copper metabolism yielding marked motor deficits, including a severely disabling tremor. As a structural correlate of the disease, a variety of cerebral abnormalities has been revealed. However, the relationship between motor deficits and cerebral lesions has remained largely unknown. Here, we investigated correlation between WD tremor and cerebral magnetic resonance imaging (MRI) findings. Cerebral MRI abnormalities in 6 symptomatic WD patients were compared to findings in 6 asymptomatic WD patients and 10 healthy controls. All patients were treated with long‐term copper chelating therapy. Motor symptoms including tremor were determined by Unified Parkinson's Disease Rating Scale Part III (UPDRS‐III). MRI findings in symptomatic WD patients revealed significant symmetric T2\*‐weighted hypointense signal alterations of globus pallidus, head of the caudate nucleus, and substantia nigra. In contrast, MRI of asymptomatic WD patients did not differ from healthy controls. Correlation analysis revealed a significant positive correlation between MRI basal ganglia lesions and UPDRS action tremor score. Our results demonstrate fo
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- Author
- Martin Südmeyer; Andreas Saleh; Lars Wojtecki; Mathias Cohnen; Joachim Gross; Markus Ploner; Harald Hefter; Lars Timmermann; Alfons Schnitzler
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)