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This study compares the pharmacokinetics and pharmacology of latanoprost 0.005% without benzalkonium chloride (BAK) to latanoprost 0.005% with BAK in New Zealand white rabbits and beagles. Results showed that both formulations effectively reduced intraocular pressure (IOP) without significant differences in pharmacokinetic parameters. Latanoprost BAK-free demonstrated comparable efficacy and safety, addressing concerns associated with BAK use in glaucoma treatments.

Author

Ana

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EN