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Unexpected occasional persistence of high levels of HHV-6 DNA in sera: Detection of variants A and B by Katherine N. Ward; Anton D. Thiruchelvam; Xosé Couto-Parada is a Medicine article available to read on EtoBox.

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## Abstract Previously it was thought that in the immunocompetent human herpesvirus‐6 [HHV‐6] DNA was present transiently in serum during early primary infection but not thereafter. In this study, HHV‐6 serum IgG avidity was detected by immunofluorescence and HHV‐6 variants A/B [HHV‐6A/B] serum DNA by semi‐quantitative PCR [titre—log~10~ copies/ml] in: (a) young children <3 years old from an encephalitis Survey, and a control Anonymised Serum Bank and (b) children/adults referred for diagnosis. The results showed that 11 out of 15 children [all <2 years] with primary infection proven by seroconversion had transient low levels of serum HHV‐6B DNA [mean titre 2.6]. However, 3.3% (6/184) of Survey Children had significantly higher levels [mean titre 5.3; 2 HHV‐6A; 4 HHV‐6B; __P__ < 0.001]. Similarly high level serum DNA [mean titre 4.0; 4 HHV‐6A; 6 HHV‐6B] was found in 1.5% (10/653) of the Serum Bank Children. Moreover, seven young children 3 years old and 4 adults [3 of whom were the mothers of 3 of the young children with persisting HHV‐6] also had persisting high titre viral DNA [mean 4.2; median 108 days]. Thus in contrast to acute primary infection, where only HHV‐6B DNA is foun

Who reads Unexpected occasional persistence of high levels of HHV-6 DNA in sera: Detection of variants A and B?

Author

Katherine N. Ward; Anton D. Thiruchelvam; Xosé Couto-Parada

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)

Published

2005

Language

EN

Field

Medicine (Health Sciences)