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Magnetic Resonance Imaging of Blood–spinal Cord Barrier Disruption in Mice with Experimental Autoimmune Encephalomyelitis by Angela E. Schellenberg; Richard Buist; V. Wee Yong; Marc R. Del Bigio; James Peeling is a Medicine article available to read on EtoBox.

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## Abstract Inflammation, demyelination, and blood‐spinal cord barrier (BSB) breakdown occur in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. The purpose of this study was to evaluate the utility of MRI for detecting lesions and BSB disruption in vivo during EAE in the mouse lumbar spinal cord, to determine how MR features of BSB disruption change during the course of disease, and to relate such changes to clinical signs and histological features of disease. Following induction of EAE in C57BL/6 mice, contrast‐enhanced (CE) __T__~1~‐weighted MR images were acquired to detect BSB disruption in the lumbar spinal cord at the early stage of disease, at peak disease, and at remission, and __T__~2~‐weighted images were obtained to monitor spinal cord morphology. Following imaging the spinal cords were assessed in situ for general features of inflammation, BSB leakage, activated macrophages/microglia, and demyelination. No focal lesions were evident on __T__~2~‐weighted MR images. BSB disruption was greatest at the onset of signs of disease, and decreased progressively thereafter. Inflammation and demyelination were pronounced at the initial stage

Who reads Magnetic Resonance Imaging of Blood–spinal Cord Barrier Disruption in Mice with Experimental Autoimmune Encephalomyelitis?

Author

Angela E. Schellenberg; Richard Buist; V. Wee Yong; Marc R. Del Bigio; James Peeling

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

2007

Language

EN

Field

Medicine (Health Sciences)