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Cocrystallization via planetary milling: Enhancing throughput of solid-state screening methods by Stephen R. Bysouth; Joanna A. Bis; David Igo is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

What is Cocrystallization via planetary milling: Enhancing throughput of solid-state screening methods about?

The application of a novel modified planetary mill, with the capacity to process 48 samples in parallel, to the rapid screening of pharmaceutical cocrystals via grinding is demonstrated for carbamazepine/saccharin, caffeine/oxalic acid, and caffeine/maleic acid cocrystals. Milling is performed directly in standard glass vials therefore no vessel decontamination is needed or sample loss occurs. Furthermore, successive sample processing can be employed without the need for additional material, making the system suitable for screening compounds of limited availability. Use of the system in an automated screening workflow of dispensing, milling, and analysis with high-throughput is also discussed.

Who reads Cocrystallization via planetary milling: Enhancing throughput of solid-state screening methods?

Author

Stephen R. Bysouth; Joanna A. Bis; David Igo

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2011

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)