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Molecular evaluation of ablative therapy of Barrett's oesophagus by Mariska Hage; Peter D Siersema; Kees J Vissers; Ewout W Steyerberg; Jelle Haringsma; Ernst J Kuipers; Herman van Dekken is a Medicine article available to read on EtoBox.

What is Molecular evaluation of ablative therapy of Barrett's oesophagus about?

## Abstract Barrett's oesophagus is a major risk factor for developing oesophageal adenocarcinoma. Ablation by argon plasma coagulation (APC) and photodynamic therapy (PDT) is currently under investigation for the removal of metaplastic and dysplastic Barrett's oesophagus. This study examined the effect of ablative therapy on Barrett's oesophagus at cell‐cycle and genetic levels. The premalignant potential of residual or recurring Barrett's oesophagus was assessed by p53 immunohistochemistry, Ki67‐related proliferative capacity, and DNA ploidy status (ie an abnormal chromosome 1 number) as measured by interphase __in situ__ hybridization. Twenty‐nine patients with Barrett's oesophagus (23 male and 6 female, mean age 58 years, mean length of Barrett's oesophagus 4 cm) were treated with APC or PDT. Intestinal metaplasia without dysplasia was present in 16 patients, low‐grade dysplasia in five, and high‐grade dysplasia in eight patients. Biopsy samples were obtained at regular intervals (mean follow‐up 20 months, range 6–36 months). One month after the first ablation, Barrett's oesophagus was no longer identified, either endoscopically or histologically, in nine patients (32%). At thi

Who reads Molecular evaluation of ablative therapy of Barrett's oesophagus?

Author

Mariska Hage; Peter D Siersema; Kees J Vissers; Ewout W Steyerberg; Jelle Haringsma; Ernst J Kuipers; Herman van Dekken

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

2004

Language

EN

Field

Medicine (Health Sciences)