Can I read Black Phosphorus Nanosheets-based Platform for Targeted Chemo-photothermal Synergistic Cancer Therapy on EtoBox?

Black Phosphorus Nanosheets-based Platform for Targeted Chemo-photothermal Synergistic Cancer Therapy by Peng, Feifei; Zhao, Fangxue; Shan, Linwei; Li, Ruirui; Jiang, Shanshan; Zhang, Peng is a Materials Science article available to read on EtoBox.

What is Black Phosphorus Nanosheets-based Platform for Targeted Chemo-photothermal Synergistic Cancer Therapy about?

As a new member of two-dimensional (2D) nanomaterials, black phosphorus (BP) has been considered as efficient photothermal therapy (PTT) agents owing to its excellent photothermal efficiency and biodegradability. Herein, a multifunctional nanoplatform based on black phosphorus nanosheets (BP NSs) was developed for chemo-photothermal synergistic cancer therapy. The BP NSs were successfully prepared by a liquid exfoliation technique. Doxorubicin (DOX), as a model drug, was loaded into the cavity of poly (amidoamine) (PAMAM) dendrimer using thin film hydration method. Then, PAMAM@DOX was coated on the surface of BP NSs using an electrostatic adsorption method that combined bath sonication with magnetic stirring. Hyaluronic acid (HA) was also modified onto the BP NS-PAMAM@DOX through electrostatic adsorption. PAMAM and HA layer could effectively isolate BP NSs from water and air to improve physiological stability. BP NSs and BP NS-PAMAM@DOX-HA were characterized by particle size, zeta potential, morphology, UV-vis-NIR absorption spectra, stability, photothermal performance and photothermal stability. This nanosystem exhibited a good pH and near infrared (NIR) dual-responsive drug relea

Who reads Black Phosphorus Nanosheets-based Platform for Targeted Chemo-photothermal Synergistic Cancer Therapy?

Author

Peng, Feifei; Zhao, Fangxue; Shan, Linwei; Li, Ruirui; Jiang, Shanshan; Zhang, Peng

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0927-7765)

Published

2020

Language

EN

Field

Materials Science (Physical Sciences)