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Posttransplantation prophylaxis with primary high-dose hepatitis B immunoglobulin monotherapy and complementary preemptive antiviral add-on: Posttransplantation Hepatitis B Prophylaxis by Shin Hwang; Chul-Soo Ahn; Gi-Won Song; Ki-Hun Kim; Deok-Bog Moon; Heung-Bum Oh; Young-Suk Lim; Han Chu Lee; Tae-Yong Ha; Dong-Hwan Jung; Young-Hwa Chung; Sung-Gyu Lee is a Medicine article available to read on EtoBox.
What is Posttransplantation prophylaxis with primary high-dose hepatitis B immunoglobulin monotherapy and complementary preemptive antiviral add-on: Posttransplantation Hepatitis B Prophylaxis about?
A considerable proportion of liver transplantation recipients who receive hepatitis B immunoglobulin (HBIG) monotherapy for hepatitis B virus (HBV) prophylaxis develop resistance to HBIG. We retrospectively assessed the efficacy of HBV prophylaxis in 1524 patients who received primary high-dose HBIG monotherapy (n 1⁄4 1463) or with a preemptive antiviral add-on as secondary combination therapy (n 1⁄4 61). At a median follow-up time of 57 months, 106 (7.3%) patients receiving HBIG monotherapy experienced HBV recurrence, with a 10-year HBV recurrence rate of 9.8%, compared to none of the patients receiving preemptive combination therapy (P 1⁄4 0.047). Thirteen patients (12.3%) with HBV recurrence failed antiviral therapy, leading to death or retransplantation. Response rates to rescue therapy before and after use of adefovir/entecavir were 44.4% and 91.8%, respectively. Acute exacerbation was not associated with treatment failure, but required prolonged treatment. Of 84 surviving patients with HBV recurrence, 44 (52.4%) showed no evidence of blood HBV DNA. The Gly145Arg mutation was found in 11 of 15 (73.3%) patients, whereas 25 of 71 (35.2%), 2 of 29 (6.9%), and 4 of 8 (50%) patient
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- Author
- Shin Hwang; Chul-Soo Ahn; Gi-Won Song; Ki-Hun Kim; Deok-Bog Moon; Heung-Bum Oh; Young-Suk Lim; Han Chu Lee; Tae-Yong Ha; Dong-Hwan Jung; Young-Hwa Chung; Sung-Gyu Lee
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)