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Alcohol Modulates Cytokine Secretion and Synthesis in Human Fetus: an in Vivo and in Vitro Study by Balwant Ahluwalia; Barbara Wesley; Olanrewaju Adeyiga; Deborah M Smith; Anita Da-Silva; Shakuntala Rajguru is a Medicine article available to read on EtoBox.

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It is well recognized that alcohol passes through the placenta and affects the fetal immune system. The underlying mechanism accounting for immune suppression is not clear. Cytokines are recognized as the principal mediators of a variety of immunologic and pathophysiologic events. The study was designed to examine whether alcohol use during pregnancy affects cytokine synthesis and secretion in the human fetus. Fetal (cord blood) and mother's blood were used for the study. Studies were conducted in vivo and in vitro. For the in vivo study, cytokine levels were measured in cord blood in mothers who drank moderate to heavy (chronic) amounts of alcohol during pregnancy. For the in vitro study, cord blood was obtained from mothers who were drug -free throughout pregnancy. Lymphocytes were isolated and stimulated with lipopolysaccharide (LPS; Escherichia coli, 26:B6). The capacity of lymphocytes to synthesize cytokines was examined in the presence of 20, 50, and 100 mM alcohol. Among the cytokines examined were the tumor necrosis factor (TNF a) and interleukins (IL -1 a and b and IL -6). The selection of cytokines was based on their presumptive role in the pathophysiology of alcoholism.

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Author

Balwant Ahluwalia; Barbara Wesley; Olanrewaju Adeyiga; Deborah M Smith; Anita Da-Silva; Shakuntala Rajguru

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0741-8329)

Published

2000

Language

EN

Field

Medicine (Health Sciences)